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Disease Reports

Company ReportsAkebia Therapeutics

Akebia Therapeutics(AKBA)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Vafseo	Vadadustat	2023-04-24		Chronic renal insufficiency , Anemia

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

drug interactions

,

,

hepatic insufficiency

,

pharmacokinetics

,

chronic kidney failure

,

,

respiratory distress syndrome

,

coronavirus infections

,

acute lung injury

,

newborn respiratory distress syndrome

,

,

,

kidney diseases

,

chronic renal insufficiency

,

healthy volunteers/patients

large b-cell lymphoma diffuse

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

,

,

,

hodgkin disease

,

mantle-cell lymphoma

,

b-cell lymphoma

,

triple negative breast neoplasms

,

renal cell carcinoma

,

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

parkinson disease

,

parkinsonian disorders

,

movement disorders

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

chronic renal insufficiency

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

graft vs host disease

,

type 1 diabetes mellitus

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

brain neoplasms

,

,

oligodendroglioma

,

pancreatic neoplasms

,

,

neuroendocrine tumors

,

islet cell carcinoma

,

,

,

somatostatinoma

,

,

,

breast neoplasms

,

myelodysplastic syndromes

,

thrombocytopenia

,

,

,

,

retinal vein occlusion

,

vision disorders

,

,

macular degeneration

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

juvenile arthritis

,

,

kidney diseases

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

organ transplantation

,

wet macular degeneration

,

neoplasm metastasis

,

graft rejection

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

non-alcoholic fatty liver disease

,

,

postoperative pain

,

,

choroidal neovascularization

,

pathologic neovascularization

,

chronic kidney failure

,

renal insufficiency

,

liver transplantation

,

kidney transplantation

,

,

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

liver cirrhosis

,

,

atrial fibrillation

Calcium carbonate

metabolic bone diseases

,

Sodium chloride

,

,

,

knee osteoarthritis

,

aortic valve stenosis

,

pathologic constriction

,

von willebrand diseases

,

,

,

tibial meniscus injuries

healthy volunteers/patients

,

,

pituitary dwarfism

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

myeloid leukemia

,

erythroblastic leukemia acute

,

,

,

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

respiratory insufficiency

,

rheumatoid arthritis

,

,

bacterial infections

,

,

,

colonic neoplasms

,

,

sleep deprivation

,

hyperlipidemias

,

diabetic neuropathies

,

alzheimer disease

,

,

streptococcal infections

,

adrenal insufficiency

,

cocaine-related disorders

,

motor neuron disease

,

airway extubation

,

,

systemic lupus erythematosus

,

,

,

,

factor xi deficiency

,

primary myelofibrosis

,

ebola hemorrhagic fever

,

marburg virus disease

,

metabolic bone diseases

,

amyotrophic lateral sclerosis

,

overactive urinary bladder

,

,

,

bacterial meningitis

,

neisseriaceae infections

,

staphylococcal skin infections

,

infectious skin diseases

,

,

malformed nails

,

pachyonychia congenita

,

palmoplantar keratoderma

,

,

colorectal neoplasms

,

cognitive dysfunction

,

,

retinal diseases

,

chronic disease

,

non-small-cell lung carcinoma

,

pure red-cell aplasia

,

sleep wake disorders

,

postoperative pain

,

myeloid leukemia

,

,

,

hemodiafiltration

,

,

,

irritable bowel syndrome

,

,

,

ovarian neoplasms

,

immunosuppression therapy

,

heart disease risk factors

,

,

,

pituitary neoplasms

,

,

,

substance-related disorders

,

,

myeloid leukemia acute

,

,

post-acute covid-19 syndrome

,

bcr-abl positive chronic myelogenous leukemia

,

chronic kidney disease-mineral and bone disorder

,

renal cell carcinoma

,

wasting syndrome

,

,

deficiency diseases

,

squamous cell carcinoma

,

,

,

olfaction disorders

,

feeding behavior

,

post-traumatic stress disorders

,

traumatic stress disorders

,

premature birth

,

,

,

alcohol-related disorders

,

prediabetic state

,

chronic hepatitis b

,

systolic heart failure

,

reperfusion injury

,

squamous cell carcinoma of head and neck

,

,

encephalomyelitis

,

esophageal neoplasms

,

,

cardiovascular abnormalities

,

replacement arthroplasty knee

,

immunoglobulin light-chain amyloidosis

,

,

end stage liver disease

,

acute-phase reaction

,

clinical deterioration

,

obsessive-compulsive disorder

,

compulsive personality disorder

,

pathologic dilatation

,

staphylococcus aureus

,

,

breast neoplasms

,

neoplasm metastasis

,

prostatic neoplasms

,

,

,

,

,

,

,

chronic obstructive pulmonary disease

,

,

,

thromboembolism

,

brain neoplasms

,

,

,

,

,

pituitary acth hypersecretion

,

type 1 diabetes mellitus

,

chronic fatigue syndrome

,

iga glomerulonephritis

,

liver cirrhosis

,

,

anxiety disorders

,

iron deficiencies

,

adrenocortical hyperfunction

,

,

restless legs syndrome

,

,

hematologic neoplasms

,

,

staphylococcal infections

,

nephrosclerosis

,

,

,

vascular access devices

,

disease progression

,

male breast neoplasms

,

acth-secreting pituitary adenoma

,

pulmonary hypertension

,

iron-deficiency anemia

,

congenital adrenal hyperplasia

,

adrenogenital syndrome

,

,

uterine cervical neoplasms

,

psychomotor agitation

,

,

,

,

second primary neoplasms

,

,

hodgkin disease

,

hypoalbuminemia

,

critical illness

,

,

hip osteoarthritis

,

myelodysplastic syndromes

,

obstructive lung diseases

,

,

,

,

pharmacological phenomena

,

catheter-related infections

,

large b-cell lymphoma diffuse

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

systemic inflammatory response syndrome

,

drug resistance

,

respiratory distress syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

transient ischemic attack

,

peripheral catheterization

,

,

intestinal pseudo-obstruction

,

,

,

,

chinese traditional medicine

,

myeloproliferative disorders

,

precancerous conditions

,

myelodysplastic-myeloproliferative diseases

,

lymphoproliferative disorders

,

,

,

hemolytic-uremic syndrome

,

malignant hypertension

,

,

hypertensive crisis

,

chronic kidney failure

,

kidney diseases

,

renal insufficiency

,

chronic renal insufficiency

,

,

,

,

diabetes mellitus

,

cardiovascular diseases

,

kidney transplantation

,

,

healthy volunteers/patients

,

type 2 diabetes mellitus

,

,

,

arteriovenous fistula

,

hyperphosphatemia

,

hyperparathyroidism

,

,

,

secondary hyperparathyroidism

,

,

,

,

,

,

acute kidney injury

,

chronic hepatitis c

,

,

communicable diseases

,

,

peritoneal dialysis

,

diabetic nephropathies

,

multiple myeloma

,

plasma cell neoplasms

,

vascular calcification

,

depressive disorder

,

,

,

insulin resistance

,

,

,

,

coronary disease

,

atherosclerosis

,

renal replacement therapy

,

left ventricular hypertrophy

,

,

vascular stiffness

,

,

chronic hepatitis

,

,

head and neck neoplasms

,

coronary artery disease

,

,

polycystic kidney diseases

,

,

myocardial ischemia

,

delayed graft function

,

graft rejection

,

pharmacokinetics

,

hypersensitivity

,

autosomal dominant polycystic kidney

,

,

oxidative stress

,

pituitary diseases

,

latent tuberculosis

,

atrial fibrillation

,

hypercholesterolemia

,

,

,

,

acute coronary syndrome

,

renal hypertension

,

mental disorders

,

,

disorders of excessive somnolence

,

pathologic constriction

,

,

,

heart transplantation

,

,

,

,

chronic periodontitis

,

hypopituitarism

,

brachial plexus block

,

metabolic diseases

,

phosphorus metabolism disorders

,

acquired immunodeficiency syndrome

,

,

neuromuscular blockade

,

graft vs host disease

,

,

renovascular hypertension

,

renal artery obstruction

,

esophageal motility disorders

,

diffuse esophageal spasm

,

human influenza

,

,

attention deficit disorder with hyperactivity

,

prospective studies

,

single-blind method

,

hypothalamic diseases

,

,

diabetes insipidus

,

neurogenic diabetes insipidus

,

social isolation

,

macular degeneration

,

wet macular degeneration

,

,

sleep apnea syndromes

,

,

,

major depressive disorder

,

wounds and injuries

,

peripheral arterial disease

,

,

obstructive sleep apnea

,

peripheral vascular diseases

,

,

cardiac arrhythmias

,

palliative care

,

decision making

,

,

venous thromboembolism

,

myocardial infarction

,

,

sleep initiation and maintenance disorders

,

,

,

non-alcoholic fatty liver disease

,

,

stomach neoplasms

,

,

,

decision support techniques

,

,

,

arteriosclerosis

,

,

pulmonary embolism

,

,

sudden death cardiac

,

water intoxication

,

congenital abnormalities

,

cushing syndrome

,

knee osteoarthritis

,

,

inferior wall myocardial infarction

,

continuous ambulatory peritoneal dialysis

,

drug-related side effects and adverse reactions

,

,

chronobiology disorders

,

fallopian tube neoplasms

,

ovarian epithelial carcinoma

,

female genital neoplasms

,

,

medication adherence

,

vitamin d deficiency

,

,

,

taste disorders

,

diabetic angiopathies

,

diabetes complications

,

diabetic retinopathy

,

immunologic deficiency syndromes

,

multiple sclerosis

,

cystic fibrosis

,

inflammatory bowel diseases

,

psychotic disorders

,

,

,

immunologic monitoring

,

cross infection

,

pregnancy-induced hypertension

,

cardiogenic shock

,

,

,

carotid intima-media thickness

,

,

,

,

intervertebral disc displacement

,

,

,

,

,

food diet and nutrition

,

,

,

,

,

vascular diseases

,

cardio-renal syndrome

,

germ cell and embryonal neoplasms

,

testicular neoplasms

,

venous thrombosis

,

respiratory tract infections

,

home hemodialysis

,

papillomavirus infections

,

,

,

gastrointestinal neoplasms

,

abdominal aortic aneurysm

,

,

aortic aneurysm

,

thrombocytopenia

,

child mortality

,

,

metabolic syndrome

,

,

parathyroid diseases

,

drug hypersensitivity

,

circadian rhythm

,

,

vascular graft occlusion

,

,

ventricular remodeling

,

patient satisfaction

,

,

,

foot and mouth disease hand

,

,

foot-and-mouth disease

,

kidney neoplasms

,

hyperhomocysteinemia

,

protein-energy malnutrition

,

food preferences

,

sedentary behavior

,

,

glomerulonephritis

,

severe acute respiratory syndrome

,

respiratory aspiration

,

,

gynecologic surgical procedures

,

pneumoperitoneum

,

altitude sickness

,

,

exercise tolerance

,

endomyocardial fibrosis

,

parkinson disease

,

feasibility studies

,

,

primary immunodeficiency diseases

,

common variable immunodeficiency

,

alcoholic fatty liver

,

chromosome aberrations

,

,

,

,

hematologic diseases

,

severe acute respiratory syndrome-related coronavirus

,

musculoskeletal diseases

,

,

,

biliary liver cirrhosis

,

,

,

chronic pancreatitis

,

,

exocrine pancreatic insufficiency

,

,

pancreatic cyst

,

,

schizophrenia spectrum and other psychotic disorders

,

status epilepticus

,

facial paralysis

,

,

,

wound infection

,

,

prostatic hyperplasia

,

addictive behavior

,

,

physical fitness

,

,

,

cell transplantation

,

out-of-hospital cardiac arrest

,

,

blood coagulation disorders

,

hemostatic disorders

,

bipolar disorder

,

vascular remodeling

,

,

muscular diseases

,

,

lower urinary tract symptoms

,

electric stimulation

,

,

dental implants

,

nociceptive pain

,

central nervous system sensitization

,

systemic scleroderma

,

diffuse scleroderma

,

,

echocardiography

,

asymptomatic diseases

,

gastrointestinal hemorrhage

,

,

,

child development

,

neurodevelopmental disorders

,

,

cerebellar ataxia

,

castration-resistant prostatic neoplasms

,

,

meningococcal meningitis

,

,

urologic neoplasms

,

,

,

,

patient compliance

,

,

,

,

mean platelet volume

,

femoral neck fractures

,

,

,

patient participation

,

cardiorespiratory fitness

,

myocardial stunning

,

pelvic floor disorders

,

familial hypophosphatemic rickets

,

hypophosphatemic rickets

,

,

intrauterine devices

,

trigeminal neuralgia

,

,

,

,

,

mesenchymal stem cell transplantation

,

chronic limb-threatening ischemia

,

low-level light therapy

,

,

intermittent claudication

,

,

chronic brain injury

,

,

intraocular pressure

,

retinal detachment

,

vitreous detachment

,

,

,

dissociative disorders

,

basal cell carcinoma

,

,

social behavior

,

cerebrovascular disorders

,

,

cognition disorders

,

upper extremity deep vein thrombosis

,

pulmonary vein stenosis

,

central venous catheterization

,

intestinal diseases

,

,

urinary tract infections

,

,

,

,

,

gastroenteritis

,

,

hematopoietic stem cell transplantation

,

,

aortic valve stenosis

,

turner syndrome

,

gonadal dysgenesis

,

lung transplantation

,

cardiac surgical procedures

,

resistance training

,

transplantation

,

organ transplantation

,

immunocompromised host

,

emission-computed tomography single-photon

,

radioisotope diagnostic techniques

,

genetic predisposition to disease

,

,

,

essential hypertension

,

,

,

maxillofacial abnormalities

,

craniofacial abnormalities

,

blood platelet disorders

,

aids-associated nephropathy

,

failure to thrive

,

addison disease

,

vitamin k deficiency

,

congenital heart defects

,

hospitalization

,

,

,

,

,

,

root canal obturation

,

,

,

,

aortic diseases

,

,

,

,

pulmonary eosinophilia

,

,

,

glycogen storage disease type ii

,

muscular atrophy

,

spinal muscular atrophy

,

inclusion body myositis

,

spinal muscular atrophies of childhood

,

atopic dermatitis

,

,

mitochondrial diseases

,

patient reported outcome measures

,

,

meniere disease

,

psychosocial functioning

,

extracorporeal membrane oxygenation

,

,

rotator cuff injuries

,

aortic dissection

,

vascular malformations

,

urologic diseases

,

arteriovenous malformations

,

vascular fistula

,

microbial drug resistance

,

cardiomyopathies

,

multiple organ failure

,

,

bariatric surgery

,

bacterial endocarditis

,

,

,

,

,

unconsciousness

,

muscle relaxation

,

blood transfusion

,

precursor cell lymphoblastic leukemia-lymphoma

,

hepatorenal syndrome

,

dna repair-deficiency disorders

,

xeroderma pigmentosum

,

trichothiodystrophy syndromes

,

,

cockayne syndrome

,

musculoskeletal abnormalities

,

,

recreational drug use

,

,

rh isoimmunization

,

,

plantar fasciitis

,

,

,

,

nephrotic syndrome

,

,

rectal neoplasms

,

caregiver burden

,

pancreatic neoplasms

,

cytomegalovirus infections

,

cytomegalovirus

,

spinal cord injuries

,

stevens-johnson syndrome

,

,

peripheral nervous system diseases

,

nutritional support

,

,

subacute thyroiditis

,

,

uterine cervical dysplasia

,

,

muscle strength dynamometer

,

prehypertension

,

endovascular procedures

,

lupus nephritis

,

myelodysplastic syndromes

,

,

,

,

chronic hepatitis c

,

,

chronic hepatitis

,

,

breast neoplasms

,

,

renal insufficiency

,

kidney transplantation

,

chronic renal insufficiency

,

kidney diseases

healthy volunteers/patients

,

type 2 diabetes mellitus

,

,

diabetes mellitus

,

,

diabetic nephropathies

,

kidney diseases

,

Microcrystalline cellulose

,

small cell lung carcinoma

,

,

falciparum malaria

,

,

hepatic insufficiency

,

myelodysplastic syndromes

,

,

,

lymphoid leukemia

,

b-cell chronic lymphocytic leukemia

,

dermatomyositis

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

non-hodgkin lymphoma

,

,

,

,

,

,

,

cerebral hemorrhage

,

hemorrhagic stroke

,

essential thrombocythemia

,

polycythemia vera

,

primary myelofibrosis

,

,

,

lupus nephritis

,

,

peritoneal neoplasms

,

intestinal obstruction

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

t-cell leukemia

,

b-cell leukemia

,

basal cell carcinoma

,

,

basal cell nevus syndrome

,

basal cell neoplasms

,

,

,

graft vs host disease

,

bronchiolitis obliterans syndrome

,

multiple myeloma

,

plasma cell neoplasms

,

alzheimer disease

,

cognitive dysfunction

,

,

renal insufficiency

,

chronic renal insufficiency

,

kidney diseases

,

,

hyperphosphatemia

,

myeloid leukemia acute

,

myeloid leukemia

,

chronic inflammatory demyelinating polyradiculoneuropathy

,

polyradiculoneuropathy

,

human influenza

,

renal cell carcinoma

,

hepatocellular carcinoma

,

,

liver neoplasms

,

gastrointestinal stromal tumors

,

,

multiple sclerosis

,

,

relapsing-remitting multiple sclerosis

,

kidney transplantation

,

type 2 diabetes mellitus

,

chronic progressive multiple sclerosis

,

diabetes mellitus

,

neoplasm metastasis

,

healthy volunteers/patients

,

,

retinal vein occlusion

,

nerve degeneration

,

,

,

depressive disorder

,

neurobehavioral manifestations

,

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

,

,

,

cataract extraction

,

capsule opacification

,

,

disease progression

hypertriglyceridemia

,

cardiovascular diseases

,

healthy volunteers/patients

,

gastrointestinal diseases

,

digestive system diseases

healthy volunteers/patients

,

muscular atrophy

,

spinal muscular atrophy

,

autism spectrum disorder

,

pharmacokinetics

,

,

,

ocular hypertension

,

open-angle glaucoma

,

multiple myeloma

,

plasma cell neoplasms

,

healthy volunteers/patients

,

erectile dysfunction

,

,

neoplasm metastasis

,

,

,

breast neoplasms

,

prostatic neoplasms

,

,

pancreatic neoplasms

,

castration-resistant prostatic neoplasms

,

triple negative breast neoplasms

,

,

,

colorectal neoplasms

,

stomach neoplasms

,

,

biliary tract neoplasms

,

,

b-cell lymphoma

,

endometrial neoplasms

,

hepatocellular carcinoma

,

esophageal neoplasms

,

liver neoplasms

,

small cell lung carcinoma

,

disease progression

,

chronic hepatitis

,

,

gastrointestinal diseases

,

,

rna virus infections

,

digestive system diseases

,

viral hepatitis human

,

flaviviridae infections

,

general anesthesia

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

obstructive sleep apnea

,

sleep apnea syndromes

,

,

,

disorders of excessive somnolence

,

,

papillomavirus infections

,

uterine cervical neoplasms

,

vaginal neoplasms

,

vulvar neoplasms

,

condylomata acuminata

,

hodgkin disease

,

migraine disorders

,

atherosclerosis

,

pancreatic ductal carcinoma

,

uterine neoplasms

,

,

mullerian mixed tumor

,

,

esophageal squamous cell carcinoma

,

large b-cell lymphoma diffuse

,

neuroendocrine tumors

,

intestinal neoplasms

,

head and neck neoplasms

,

prostatic hyperplasia

,

,

muscular atrophy

,

,

,

urologic neoplasms

,

transitional cell carcinoma

,

urinary bladder neoplasms

,

microsatellite instability

,

non-small-cell lung carcinoma

,

chronic hepatitis c

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

,

,

,

urinary tract infections

,

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

,

,

polycystic kidney diseases

,

,

spondylarthritis

,

,

axial spondyloarthritis

,

,

postherpetic neuralgia

,

,

,

,

,

,

communicable diseases

,

,

acquired immunodeficiency syndrome

,

ovarian neoplasms

,

,

,

,

,

,

kidney diseases

,

rheumatoid arthritis

,

,

ovarian epithelial carcinoma

,

hepatitis a virus

,

immunosuppression therapy

,

,

chronic renal insufficiency

,

chronic disease

,

drug-related side effects and adverse reactions

,

non-hodgkin lymphoma

,

follicular lymphoma

1

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